OERC taxonomy

(After Abeloff, et al. Clinical Oncology, 2004)
I. Biology of Cancer
a. Biology of Metastases
b. Cell cycle control
c. Cell life and death
d. Immunology and cancer
e. Stem cells
f. Cell differentiation and cancer
g. Angiogenesis and cancer
II. Genesis of cancer (carcinogenesis)
a. Environmental factors
b. DNA damage response and cancer
c. Viruses and human cancer
d. Genetic factors: hereditary cancer syndromes
e. Genetic factors: cancer susceptibility genes
f. Gene mutations and cancer
g. Immunodeficiency and cancer
III. Cancer diagnosis
a. Pathology and laboratory medicine
i. Surgical pathology
ii. Flow cytometry in cancer diagnosis
iii. Immunohistochemistry
iv. Cytogenetics (karyotyping and FISH)
v. Molecular diagnosis of cancer
vi. Tumor markers
vii. Tumor imaging (radiology): CT, MRI, PET, ultrasound
IV. Cancer control
a. Epidemiology and population science of cancer
b. Cancer prevention
c. Cancer screening
d. Cancer economics and social issues
e. Early detection of cancer
V. Clinical trials
a. Biostatistics for clinical trials
b. Clinical trials in cancer: trial design, types of trials
c. Analysis of clinical trials: levels of evidence
VI. Cancer therapy (general considerations)
a. Pharmacology of anticancer drugs (chemotherapy)
i. Cytotoxics
ii. Antimetabolites
iii. Antiangioangiogenic agents
iv. Molecular targeted therapies (e.g. tyrosine kinase inhibitors)
v. Endocrine agents
vi. Monoclonal antibodies
vii. Radioimmunotherpy
b. Multiagent chemotherapy
c. Multimodality cancer treatment
d. RADIATION THERAPY (to be expanded)
e. CANCER SURGERY (to be expanded)
i. Vascular access
ii. Acute abdomen, bowel obstruction and fistula
f. Stem cell transplantation
g. Gene therapy
h. Cancer vaccines
i. Complimentary and alternative therapies
VII. Palliative care of the cancer patient
a. Symptom management
i. Pain
ii. Rehabilitation
iii. Cachexia
iv. Nausea and vomiting
v. Mucositis and oral complications
vi. Cutaneous complications and alopecia
vii. Fatigue
viii. Lymphedema
ix. End of life care and hospice
x. Psychosocial problems of cancer patients
VIII. Hematologic problems in the cancer patient
a. Anemia
b. Leucopenia
c. Thrombocytopenia and hemorrhagic problems
d. Immunodeficiency
e. Thrombosis
IX. Infections in the cancer patient
a. Neutropenic fever
b. Infections in immunocompromised host
X. Metabolic and paraneoplastic syndromes in cancer
a. Hypercalcemia
b. Hyponatremia and hypomagnesemia
c. Tumor lysis syndrome
d. Paraneoplastic neurologic syndromes
XI. Complications of cancer and and metastases
a. Superior vena cava syndrome
b. Spinal cord compression (and nerve root compression)
c. Brain metastases and carcinomatous meningitis
d. Bone metastases
e. Lung metastases and pleural effusions
f. Liver metastases
g. Ascites
h. Neurologic complications
i. Organ toxicity of cancer treatment
i. Lung
ii. Liver
iii. Reproductive system
iv. Kidney
v. Endocrine system
XII. Secondary malignant neoplasms
XIII. Cancer and pregnancy
XIV. Cancer in the elderly
XV. Specific malignancies
a. Primary brain and central nervous system cancer
b. Cancer of the eye and orbit
c. Head and neck cancer
d. Melanoma
e. Basal and squamous cell skin cancers
f. Other non-melanoma skin cancers
g. Cancer of the endocrine system (thyroid, adrenal, etc.)
h. Lung cancer
i. Tumors of the pleural and mediastinum
j. Esophageal cancer
k. Gastric cancer
l. Small bowel cancer
m. Colon cancer
n. Rectal cancer
o. Anal cancer
p. Liver and bile duct cancer
q. Pancreas cancer
r. Kidney cancer
s. Bladder cancer
t. Prostate cancer
u. Cancer of penis and urethra
v. Testicular cancer
w. Cancer of cervix, vagina and vulva
x. Uterine cancer
y. Cancer of ovaries and fallopian tubes
z. Gestational trophoblastic cancers
aa. Breast cancer
bb. Sarcoma of bone
cc. Soft tissue sarcomas
dd. Carcinoma of unknown primary
ee. HIV-associated malignancies
ff. Solid tumors in children
gg. Childhood leukemia
hh. Childhood lymphoma
ii. Acute lymphoid leukemia
jj. Acute myeloid leukemia
kk. Myelodysplastic syndromes
ll. Myeloproliferative disorders
mm. Chronic myeloid leukemia
nn. Chronic lymphoid leukemias
oo. Hairy cell leukemia
pp. Multiple myeloma and monoclonal gammopathy
qq. Waldenstrom macroglobulinemia
rr. Hodgkin lymphoma
ss. Non-Hodgkin lymphomas
tt. Cutaneous T and B cell lymphomas
uu. Adult T-cell leukemia-lymphoma

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